《柳叶刀杂志》已创刊180多年，是世界上最权威和历史悠久的综合性理论医学刊物之一。它与New England Journal of Medicine，JAMA并列为世界最有影响医学杂志。 格林威治时间2008年5月23日中午12点（北京时间22日晚上20点）《柳叶刀杂志》在伦敦卡姆登发布新闻，公布中国大庆糖尿病预防研究跟踪随访20年成果。
该研究论文将在2008年6月美国糖尿病学会年会及最近一期柳叶刀杂志‘糖尿病与心血管疾病特刊’上发表并配有评论员文章。该项研究由中日友好医院内分泌代谢中心联合大庆市第一医院，在美国疾病控制中心和世界卫生组织资助和中国卫生部疾控司支持下完成。这是我院李光伟教授等在国际上首次报告饮食、运动锻炼干预对糖尿病的长达20年的预防作用及其对心血管疾病和死亡的影响。
论文摘要：
Intensive lifestyle interventions can reduce the incidence of type 2 diabetes in people with impaired glucose tolerance, but how long these benefits extend beyond the period of active intervention, and whether such interventions reduce the risk of cardiovascular disease (CVD) and mortality, is unclear. We aimed to assess whether intensive lifestyle interventions have a long-term effect on the risk of diabetes, diabetes-related macrovascular and microvascular complications, and mortality.
In 1986, 577 adults with impaired glucose tolerance from 33 clinics in China were randomly assigned to either the control group or to one of three lifestyle intervention groups (diet, exercise, or diet plus exercise). Active intervention took place over 6 years until 1992. In 2006, study participants were followed-up to assess the long-term effect of the interventions. The primary outcomes were diabetes incidence, CVD incidence and mortality, and all-cause mortality.
Compared with control participants, those in the combined lifestyle intervention groups had a 51% lower incidence of diabetes (hazard rate ratio [HRR] 0·49; 95% CI 0·33–0·73) during the active intervention period and a 43% lower incidence (0·57; 0·41–0·81) over the 20 year period, controlled for age and clustering by clinic. The average annual incidence of diabetes was 7% for intervention participants versus 11% in control participants, with 20-year cumulative incidence of 80% in the intervention groups and 93% in the control group. Participants in the intervention group spent an average of 3·6 fewer years with diabetes than those in the control group. There was no significant difference between the intervention and control groups in the rate of first CVD events (HRR 0·98; 95% CI 0·71–1·37), CVD mortality (0·83; 0·48–1·40), and all-cause mortality (0·96; 0·65–1·41), but our study had limited statistical power to detect differences for these outcomes.
Group-based lifestyle interventions over 6 years can prevent or delay diabetes for up to 14 years after the active intervention. However, whether lifestyle intervention also leads to reduced CVD and mortality remains unclear.
Centers for Disease Control and Prevention, WHO, the China-Japan Friendship Hospital, and Da Qing First Hospital.
